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Viagra - 10 years old

2008-04-20T07:15:00.000-07:00

10 years ago Viagra’s fame exploded into the men’s world. The first oral treatment for impotence quickly became one of the biggest success, no THE BIGGEST SUCCESS in pharmaceutical history leaving far away other pills.
A Viagra's main success was that it overturned the view that ED was only in the men’s mind. Stress and other pressures can affect male sexuality, dysfunction mostly has a physical cause - the first sign is when the blood vessels are clogging up (atherosclerosis). The blood vessels in the penis are the smallest in the body and impotence or ED is often an early symptom of atherosclerosis, which also is a sign for heart disease and stroke.
Those suffering from ED should check their health for diabetes, obesity, high blood pressure and abnormal cholesterol. In this time Viagra can be used to improve penile blood flow and therefore erectile function.
One in seven men doesn't respond to Viagra, however, while others have unacceptable side effects. A firmer favourite is newcomer Cialis, known for its effect that last for at least 24 hours, which means men with ED can have sex at night and again the next morning. The studies have been published showing that on the men and even their partners prefer Cialis because men get a better erection. Though the studies were funded by manufacturers of Cialis and need to be treated with caution.

2007-09-30T03:07:00.000-07:00

For a drug that flopped in clinical trials, Viagra has subsequently been an extraordinary success story. When scientists first concocted the little blue pill more than 20 years ago, it was as a treatment for the heart condition angina.
The idea was that it would ease pain by dilating blood vessels around the heart.
The results were disappointing, until doctors noticed an extraordinary side-effect among male volunteers.
"Researchers knew they were on to something when patients refused to give the drugs back at the end of the trial," says Dr Mike Kirby, adviser to the Sexual Dysfunction Association.
Viagra generates sales of more than £1 billion a year and, as well as providing effective treatment for erectile dysfunction, is attracting interest as a potential remedy for a range of other illnesses from deadly lung disorders to cold hands.
The secret of Viagra, and other drugs in the same class, is that they allow blood to flow more freely by helping arteries to relax. They do this by blocking the effects of an enzyme called phosphodiesterase.
Evidence suggests it could even be used to combat jet lag.
Below, we examine other ways the modern day wonder-drug could help repair the damaged body. In most cases, research is still at an early stage and the drug is not yet being widely used. In others, such as the deadly lung disease pulmonary arterial hypertension, a form of the drug is already being used to save lives in Britain.
HEART ATTACKS
Giving Viagra after a heart attack could repair damaged muscle by restoring oxygen supplies. Researchers at Virginia Commonwealth University in the U.S. compared the antiimpotence drug with nitroglycerin, the standard treatment given to heart attack victims, and found Viagra was better at restoring bloodflow and helping tissue heal.
BREAST CANCER
Breast and colon tumours in mice shrank threefold when they were injected with the drug in experiments at Johns Hopkins University in the U.S. Scientists believe Viagra works by 'unmasking' cancer cells, so the immune system can recognise them as foreign and destroy them.
COLD HANDS
Raynaud's disease affects up to one in five people and is caused when blood supply to fingers and toes is interrupted. Most of the time they appear cold, white and look dead, but exposure to cold can trigger a burning sensation. Patients given 50mg of Viagra twice a day, for four weeks, had fewer and much shorter 'burning' attacks due to better bloodflow.
CROHN'S DISEASE
British researchers claim the sex pill could fight Crohn's disease, a debilitating condition, which often needs major surgery on the bowel. Tests at University College London showed the drug boosts bloodflow around the small intestine - the area most affected by the disease - and helps fight bacteria..
INFERTILITY
A woman's chances of becoming pregnant could improve, according to scientists. In some women, the lining of the uterus is too thin to sustain a pregnancy. The drug increases bloodflow to the uterus and stimulates growth of cells.
DIABETES
Three out of four diabetics suffer gastroparesis - when the stomach empties too slowly. It causes loss of appetite and dehydration. U.S. scientists found Viagra helped by relaxing stomach muscles.
PELVIC PAIN
Up to 50 per cent of men suffer pelvic pain, causing discomfort around the lower back and groin.
Viagra appears to help by dilating blood vessels in the pelvic area and boosting bloodflow, according to a trial at Washington University in the U.S..
STILL BIRTHS
Every year, about 600 babies in the UK are stillborn because of a pregnancy disorder called pre-eclampsia. But foetal deaths dropped sharply in pregnant mice given the Viagra. In pre-eclampsia, arteries feeding the placenta do not widen enough to deliver all the blood the baby needs. Viagra relaxes muscles in the artery walls.
LUNG DISEASE
Nobody knows what causes pulmonary arterial hypertension, a condition that affects about 4,000 people in the UK, often women in their 30s and 40s. But few sufferers survive beyond three to four years. Blood pressure becomes dangerously high in the pulmonary artery. A Viagra-based drug called Revatio is extending the lives of some sufferers by boosting blood flow to the lungs, reducing the workload on the heart.
PROSTATE PROBLEMS
The little blue pill can improve symptoms of benign prostatic hyperplasia. BPH is part of the natural ageing process and nothing to do with prostate cancer. But it does cause frequent urinating, bladder stones, depression and daytime tiredness due to constant broken sleep. Doctors at Northwestern University in Chicago tested the drug on 300 men - it had a dramatic effect..

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2007-09-04T22:57:00.000-07:00

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Sex sells -- just turn on the TV or flip open a magazine to see that. However, try talking about senior citizens and sex.Society treats seniors like they are asexual, that sex is no longer of interest. Research shows that is not the case at all.Marilyn Renaudette, an elder clinician, remarked that her senior friends who are dating again have found it's much like a return to puberty."This is frequently a subject of conversation when the 'girls' are together," she said. "Dating is difficult due to all of the youthful expectations in our society about sex. It's important for the older generation to know that sex doesn't have to stop, but it may take 'different' forms."Today's seniors are staying active and that includes a healthy sex life. Recent advances in medicine, including Viagra, have allowed couples to continue a regular sex life. Among seniors age 75 and older with partners, 25 percent of those said they has sex at least once a week, and more than 70 percent with partners had sex at least once a month. For younger seniors the numbers are even higher: 87 percent of married men and 84 percent of married women in the 60-65 age group are sexually active.Walter Bortz, author of three books on healthy aging as well as several studies on senior's sexuality, has been quoted as saying "Use it or lose it." A Duke University study shows that some 20 percent of people over age 65 report having a better sex life now than ever before. The reasons why: Many seniors are retired; the kids are out of the house; and couples have more time to devote to their relationship.More than 85 percent of those over age 60 said that they have some sort of intimate experience, including kissing or intercourse, once a week.One alarming statistic: Seniors who are sexually active open themselves up to many of the same risks faced by younger people face. Many seniors grew up in time where people did not openly discuss sexuality. They may not understand the risk of contracting a venereal disease.Since the threat of pregnancy is not an issue, many seniors do not take precautions. Women over the age of 50 are among the fasting growing group to be infected with HIV and other venereal diseases. Those over age 50 make up 10 percent of the newest AIDS cases and 14 percent of those who are living with AIDS. Also due to physical changes, seniors are more vulnerable to infection: They may have weakened immune systems and other factors that can make them more vulnerable to venereal disease.